Blood Pressure Lowering Treatment Trialists Collaboration - BPLTTC

Aims

To provide reliable evidence about the effects of different classes of blood pressure lowering drugs on cardiovascular mortality and morbidity in a variety of patient groups.

Methods

A series of prospective overviews (meta-analyses).

Status/Results

The second cycle of analyses that included data from 29 large trials and 162,000 individuals were reported in The Lancet in November 2003. The results suggested that most types of blood pressure lowering drugs produce similar benefits and highlighted the importance of good control of blood pressure.

Since the second cycle of overviews, the findings from analyses of patients with and without diabetes have also been published in Archives of Internal Medicine.

A collaboration website - www.thegeorgeinstitute.org/bplttc/ - provides detailed information about the results and materials such as slide sets for download. Other patient subgroup analyses (age, sex and baseline blood pressure) are ongoing.

Publications

bplttc publication list

Institute Investigators

Project Manager

  • Fiona Turnbull

Collaboration

  • Principal investigators from large-scale trials worldwide, including studies conducted in Australasia, Asia, North America and Europe

Funding Agencies