Studies & Trials
Familial Intracranial Aneurysm - FIA
To identify the gene (or genes) associated with formation and rupture of intracranial aneurysm in families with multiple affected family members. This is a large-scale investigation, conducted across 23 centres internationally, to identify regions on chromosomes...
Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial - INTERACT
INTERACT aims to determine if early intensive blood pressure lowering therapy can reduce death and disability from intracerebral haemorrhage. The study is an open, blinded-endpoint, randomised controlled trial conducted in Australia, New Zealand, China, and the USA...
Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial - ONTARGET
The renin-angiotensin system (RAS) of the body may cause harmful cardiovascular effects because of trophic changes such as left ventricular hypertrophy (LVH), negative effects on endothelieal functioin and contributions to the development of atherosclerosis...
Psychosocial Outcomes in Stroke - POISE
The primary aim of this project is to determine if modifiable early (within 28 days of stroke) psychosocial factors are associated with return to work at one year in younger stroke survivors.
QUality Evaluation of Stroke Care and Treatment - ChinaQUEST
Stroke is a major cause of death and disability, and cost to healthcare around the world. With a rapidly ageing population and adverse lifestyle changes over recent decades, stroke has become a major public health issue in China, with more than one million stroke deaths occurring each year.
Sleep Apnea CardioVascular Endpoints Study - SAVE
An international research project to establish the benefits of treatment of obstructive sleep apnea (OSA) on cardiovascular outcomes...
Socioeconomic Determinants of Stroke - SEDS
Increasing the power of socioeconomic disparity analyses to reduce inequities in stroke risk and outcome: meta-analysis of 'ideal' stroke incidence studies in Australia and New Zealand.
The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial - INTERACT2
INTERACT2 aims to investigate whether early intensive blood pressure lowering therapy can reduce death and disability from intracerebral haemorrhage compared to a conservative management that is based on a current guideline for the management of intracerebral haemorrhage in clinical settings.
Trends in Stroke Incidence and Impact in Populations
This study aims to determine the impact of prevention strategies and improvements in stroke healthcare services on the incidence and outcome of stroke in different populations over recent decades. Analyses of datasets from the Auckland Regional Community Stroke Study (ARCOS) and the Perth Community Stroke Study (PCSS) will be undertaken...