Prevention of Ectopic Bone-Related Pain and Disability After Elective Hip Replacement Surgery - HIPAID
Aims
This short course of treatment could be a highly cost-effective way to reduce pain and disability after hip replacement surgery
Methods
A double-blind placebo-controlled randomised clinical trial involving 902 patients recruited from 20 orthopaedic centres in Australia and New Zealand. Patients were randomised within 24 hours post-surgery to receive either ibuprofen (1200mg daily) or matching placebo in three divided doses for 14 days.
Status/Results
Recruitment commenced early 2002 and closed end October 2003 with 902 patients randomised. The main study results have been published.
Publications
HIPAID Management Committee on behalf of the HIPAID Collaborative Group. Preventing ectopic bone-related pain and disability after hip replacement with perioperative ibuprofen. Controlled Clinical Trials 2004;25:223-233.
Fransen M, Anderson C, Douglas J, MacMahon S, Neal B, Norton R, Woodward M, Cameron I, Crawford, R, Lo SK, Tregonning G, Windolf M for the HIPAID Collaborative Group. A randomised trial evaluating the safety and efficacy of routine peri-operative ibuprofen for ectopic-bone related pain and disability after hip replacement surgery. British Medical Journal 2006; 333: 519-521
Institute Investigators:
Project Manager:
- Jan Douglas
Collaboration:
- University of Auckland, New Zealand
- Royal Prince Alfred Hospital, Sydney, Australia
- Royal North Shore Hospital, Sydney, Australia
- Rehabilitation Studies Unit, Royal Rehabilitation Centre, Sydney, Australia
- The Centre for National Research on Disability and Rehabilitation (CONROD), Australia
- Prince Charles Hospital, Brisbane, Australia
- Middlemore Hospital, New Zealand
- 17 other hospitals in Australia and New Zealand